#Hdyroxy photolinker pdf

We found that both TEPP-46 and DASA-58 suppressed the development of IL-17–producing T H17 cells but increased the generation of those producing GM-CSF. T H17 cells are believed to orchestrate MS pathology, in part, through the production of two proinflammatory cytokines: interleukin-17 (IL-17) and GM-CSF. To understand how these compounds alter T cell function, we assessed their therapeutic activity in a mouse model of T cell–mediated autoimmunity that mimics multiple sclerosis (MS). 239000001257 hydrogen Substances 0.Small molecules that promote the metabolic activity of the pyruvate kinase isoform PKM2, such as TEPP-46 and DASA-58, limit tumorigenesis and inflammation.229910052739 hydrogen Inorganic materials 0.000 claims abstract description 17.239000002831 pharmacologic agent Substances 0.000 title description 10.230000004913 activation Effects 0.000 title claims description 58.238000000034 method Methods 0.000 title claims abstract description 37.

229920000642 polymer Polymers 0.000 title claims abstract description 88.Assignors: NAHAR, PRADIP Publication of US20030228410A1 publication Critical patent/US20030228410A1/en Application granted granted Critical Publication of US7629016B2 publication Critical patent/US7629016B2/en Status Expired - Fee Related legal-status Critical Current Adjusted expiration legal-status Critical Links Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Application filed by Council of Scientific and Industrial Research CSIR filed Critical Council of Scientific and Industrial Research CSIR Priority to US10/166,292 priority Critical patent/US7629016B2/en Assigned to COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH reassignment COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Original Assignee Council of Scientific and Industrial Research CSIR Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)Ĭouncil of Scientific and Industrial Research CSIR ( en Inventor Pradip Nahar Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Granted Application number US10/166,292 Other versions US7629016B2

#Hdyroxy photolinker pdf

Google Patents Process for photochemical activation of polymer surface and immobilization of biomolecules onto the activated surfaceĭownload PDF Info Publication number US20030228410A1 US20030228410A1 US10/166,292 US16629202A US2003228410A1 US 20030228410 A1 US20030228410 A1 US 20030228410A1 US 16629202 A US16629202 A US 16629202A US 2003228410 A1 US2003228410 A1 US 2003228410A1 Authority US United States Prior art keywords activated immobilization polymer biomolecule photolinker Prior art date Legal status (The legal status is an assumption and is not a legal conclusion.

Google Patents US20030228410A1 - Process for photochemical activation of polymer surface and immobilization of biomolecules onto the activated surface US20030228410A1 - Process for photochemical activation of polymer surface and immobilization of biomolecules onto the activated surface